Attenuation of cardiac allograft vasculopathy by sirolimus: Relationship to time interval after heart transplantation
نویسندگان
چکیده
منابع مشابه
Conversion to sirolimus as primary immunosuppression attenuates the progression of allograft vasculopathy after cardiac transplantation.
BACKGROUND We investigated the potential of conversion to sirolimus (SRL) as a primary immunosuppressant in attenuating cardiac allograft vasculopathy progression. METHODS AND RESULTS Twenty-nine cardiac transplant recipients were converted to SRL 3.8+/-3.4 years after transplantation with complete calcineurin inhibitor (CNI) withdrawal. Secondary immunosuppressants (azathioprine or mycopheno...
متن کاملTransplantation Sirolimus as Primary Immunosuppression Attenuates Allograft Vasculopathy With Improved Late Survival and Decreased Cardiac Events After Cardiac Transplantation
Background—We retrospectively analyzed the potential of sirolimus as a primary immunosuppressant in the long-term attenuation of cardiac allograft vasculopathy progression and the effects on cardiac-related morbidity and mortality. Methods and Results—Forty-five cardiac transplant recipients were converted to sirolimus 1.2 years (0.2, 4.0) after transplantation with complete calcineurin inhibit...
متن کاملPrevention of Cardiac Allograft Vasculopathy in Heart Transplantation
Heart transplantation is a well established therapy for end-stage heart failure. Long-term results are limited by malignancy and cardiac allograft vasculopathy. The causes for cardiac allograft vasculopathy and the predictors for its onset and progression are multifactorial and determined by both immunological and non-immunological risk factors. The detection of cardiac allograft vasculopathy i...
متن کاملSirolimus as primary immunosuppression attenuates allograft vasculopathy with improved late survival and decreased cardiac events after cardiac transplantation.
BACKGROUND We retrospectively analyzed the potential of sirolimus as a primary immunosuppressant in the long-term attenuation of cardiac allograft vasculopathy progression and the effects on cardiac-related morbidity and mortality. METHODS AND RESULTS Forty-five cardiac transplant recipients were converted to sirolimus 1.2 years (0.2, 4.0) after transplantation with complete calcineurin inhib...
متن کاملAssessment of cardiac allograft vasculopathy late after heart transplantation: when is coronary angiography necessary?
BACKGROUND Cardiac allograft vasculopathy (CAV) represents a major prognostic factor in long-term survivors of heart transplantation (HTx). Reliable diagnosis of CAV late after HTx is important but remains the domain of invasive techniques such as coronary angiography. METHODS To test alternative approaches, 54 consecutive HTx recipients (mean time since HTx: 52 months) were studied with intr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Heart and Lung Transplantation
سال: 2013
ISSN: 1053-2498
DOI: 10.1016/j.healun.2013.05.015